ADDISON’S DISEASE CUSHING’S DISEASE Definition Hyposecretion of adrenocortical hormones leading to: Metabolic disturbances (sugar) Fluid and electrolyte imbalances (salt) Deficiency of neuromuscular function (salt and sex) Hypersecretion of adrenocortica
DISEASE = pituitary adenoma which is suppressed by high-dose dex, SYNDROME = adrenal adenoma or ACTH-secreting tumor which don't suppress with dex. Disease = cortisol Decreases with Dex, Syndrome = cortisol Stays high with dex.
Cushing's syndrome describes the signs and symptoms associated with prolonged exposure to inappropriately high levels of the hormone cortisol. This can be caused by taking glucocorticoid drugs, or diseases that result in excess cortisol, adrenocorticotrop