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DNA editing in mouse embryos prevents disease : Nature News & Comment

Destroying faulty DNA in mitochondria could be alternative to ‘three-parent embryo’.

Manipulating One Brain Protein Could Allow Us to Prevent Alzheimer's

What's this mouse brain thinking? 20 billion "magnetoelectric" nanoparticles "talk" to the brain using electric fields they produce when stimulated by an external magnetic field

Mitochondrial DNA Variations May Spur Symptoms in People with Form of Chronic Fatigue

Mitochondrial DNA Variations May Spur Symptoms in People with Form of Chronic Fatigue

Repair of Damaged Nerve Cells in Mice Improved by Boosting Mitochondria Transport - Mitochondrial Disease News

BRCA1, previously found to be involved and breast cancer and ovarian cancer, is found to play an important role in Alzheimer's Disease. This gene codes for a DNA repair protein, which appears to be central in repairing DNA in different tissues, including the brain.

Brain accumulation of beta-amyloid protein in Alzheimer's disease may cause impairments by depleting levels of a DNA repair protein produced by the breast cancer gene

Previously unknown tau pathway leading to Alzheimer's disease identified.

Previously unknown tau pathway leading to Alzheimer’s disease identified.

Previously unknown tau pathway leading to Alzheimer's disease identified.

Researchers at the University of Toronto have uncovered new insights on the genetic causes of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes.  The team state that a common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. However, it is unknown how many repeats would be sufficient to…

Human generational study pinpoints epigenetic cause of Amyotrophic Lateral Sclerosis (ALS).

Researchers at the University of Toronto have uncovered new insights on the genetic causes of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease. These findings could uncover a new way to detect a genetic predisposition to ALS before the disease strikes. The team state that a common mutation associated with ALS is an unstable repeated DNA sequence within the C9orf72 gene that could reach into the thousands. However, it is unknown how many repeats would be sufficient to…

Wandering mitochondrial DNA hint at new ways to fight disease: Scientists have watched mitochondrial DNA transfer from healthy cells into tumour cells - something that everyone assumed was biologically impossible - and it could lead to completely new ways of fighting debilitating disease.

Scientists have watched mitochondrial DNA transfer from healthy cells into tumour cells - something that everyone assumed was biologically impossible - and it could lead to completely new ways of fighting debilitating

Dna double helix - stock photo

To read more about heart disease and cholesterol, check out the special report page. In the last article in this series, I explained that LDL particle number (LDL-P) is a much more accurate predict.

By uncovering the mechanism by which fibrous tissue cells in the lung multiply, researchers at The Children's Hospital Los Angeles (CHLA), Keck School of Medicine, Nanjing Drum Tower Hospital, Instituto Nacional de Enfermedades Respiratorias, and McMaster University have identified a promising new approach for the treatment of pulmonary fibrosis. Idiopathic pulmonary fibrosis or IPF, where the disease appears spontaneously and without a known cause, is a severe, chronic lung disease in which…

Researchers map and control pulmonary fibrosis signalling pathway in preclinical trials.

By uncovering the mechanism by which fibrous tissue cells in the lung multiply, researchers at The Children's Hospital Los Angeles (CHLA), Keck School of Medicine, Nanjing Drum Tower Hospital, Instituto Nacional de Enfermedades Respiratorias, and McMaster University have identified a promising new approach for the treatment of pulmonary fibrosis. Idiopathic pulmonary fibrosis or IPF, where the disease appears spontaneously and without a known cause, is a severe, chronic lung disease in which…

A team of researchers from the University of Pittsburgh state that it might be possible to heal cirrhotic liver disease by rebooting the genes that control liver cell function. If validated in human studies, the game-changing strategy, described in an opensource study published in the Journal of Clinical Investigation, could potentially treat patients who are too sick for liver transplantation and, in the future, reduce the need for transplants.  The project grew out of the observation that…

Rebooting cell programming via precision medicine reverses liver failure in animal model.

A team of researchers from the University of Pittsburgh state that it might be possible to heal cirrhotic liver disease by rebooting the genes that control liver cell function. If validated in human studies, the game-changing strategy, described in an opensource study published in the Journal of Clinical Investigation, could potentially treat patients who are too sick for liver transplantation and, in the future, reduce the need for transplants. The project grew out of the observation that…

In a mechanism that may contribute to aging and disease, telomeres are now found to loop back and silence genes. The study, from UT Southwestern, finds that, once shortened by age, the telomeres lose the ability to switch those genes off. While previous research has focused on the role of telomeres in cell senescence, this paper explores possible adaptive roles of telomere shortening.

A novel looping mechanism that involves the end caps of DNA may help explain the aging of cells and how they initiate and transmit disease, according to new research from UT Southwestern Medical Center cell biologists.

yet of what causes schizophrenia, a condition that affects around 1% of the global population.  The team states that their work presents strong evidence that disruption of a delicate chemical balance in the brain is heavily implicated in the disorder.  In the largest ever study of its kind, the team found that disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance of which plays a crucial role in healthy brain development and…

Researchers provide strongest evidence yet of neurogenetic cause of Schizophrenia.

yet of what causes schizophrenia, a condition that affects around 1% of the global population. The team states that their work presents strong evidence that disruption of a delicate chemical balance in the brain is heavily implicated in the disorder. In the largest ever study of its kind, the team found that disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance of which plays a crucial role in healthy brain development and…