How To Treat Piriformis Syndrome | If you have pain in the buttocks and/or sciatica like pain down the back of your thigh, calf, and foot, you may have piriformis syndrome. This post has tons of helpful information - what is piriformis syndrome? what are the symptoms? what are the causes? how can I prevent it? - as well as treatment options for relief. We've included 4 stretches and 4 exercises aimed at reducing pain and strengthening your glutes.