Do It Yourself Natural Flea and Tick Spray Recipe To make this natural flea and tick home remedy, grab a spray bottle (I reused one). Then, in a spray bottle, mix the following ingredients: 8 oz. apple cider 4 oz. water 1/2 tsp. iodized salt 1/2 tsp. baking soda To use: shake up bottle and spray on pet. Brush through fur. Please note: You’ll still want to check regularly for pests, fleas and ticks and remove any you might find promptly.